DESCRIPTION
Metastasis, responsible for 90% of cancer deaths, remains poorly understood, especially in hormone-regulated cancers like prostate and breast cancer. These cancers commonly metastasize to bone, leading to complications and significantly reduced quality of life. This invention involves compositions and methods utilizing phenolic phytochemicals derived from oregano, cranberry, and Rhodiola for treating bone metastasis from cancers, particularly prostate and breast cancer. In some embodiments, the composition comprises a polymer, a clay, and a phenolic phytochemical of oregano, cranberry, or Rhodiola. In some embodiments, the polymer and clay form a scaffold that the phenolic phytochemical coats or is impregnated in the scaffold or delivered to the scaffold.
R. Crenulata reduces cell proliferation in Bone-Met PC3
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p < 0.05, **p < 0.01 ***p< 0.001. Indicate a significant difference between non-treated and treated Bone-met (BM) cultures of prostate cancer cells
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Benefits
- Targeted Therapy: specifically induces apoptosis in bone-metastasized cancer cells.
- Bone-Safe: does not harm normal bone cells, ensuring better patient outcomes.
- Versatile Application: effective against various types of cancers that metastasize to bone, including aggressive forms like triple-negative breast cancer
Applications
- Cancer Treatment: therapeutic application in treating bone metastasis from prostate and breast cancers
- Nutraceuticals: development of health supplements that could help in managing cancer metastasis
Patent
This technology has a U.S. Patent Pending and is available for licensing/partnering opportunities.
