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Phenolic Phytochemicals for Bone Metastasis of Cancer
Metastasis, responsible for 90% of cancer deaths, remains poorly understood, especially in hormone-regulated cancers like prostate and breast cancer. These cancers commonly metastasize to bone, leading to complications and significantly reduced quality of life. This invention involves compositions and methods utilizing phenolic phytochemicals derived...
Published: 11/25/2025
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Inventor(s): Dinesh Katti, Kalidas Shetty, Preetham Ravi, Dipayan Sarkar, Kalpana Katti
Keywords(s):
Category(s): Technologies > Biology & Medicine
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Low Cost Diabetes Breath Analyzer Based on Nanostructured K2W7022 Material
Scientists at NDSU have developed a glucose monitor based on acetone in exhaled breath. The detection range encompasses normal through diabetic glucose levels, enabling versatility to monitor blood glucose in diabetic and pre-diabetic individuals, as well as tracking diet and athletic performance. Results are obtained in seconds, with the acetone concentration...
Published: 11/24/2025
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Inventor(s): Danling Wang, Qifeng Zhang
Keywords(s):
Category(s): Technologies > Biology & Medicine
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Rapid Response Vaccines for Emerging RNA Viruses
Scientists at NDSU have developed a method to rapidly produce safe and efficacious vaccines against emerging RNA viruses. This is accomplished by damaging or destroying the RNA genome (so replication is diminished or eliminated) while maintaining the structural integrity of the capsid so antibodies recognize the native virus. Therefore, NDSU's method...
Published: 11/24/2025
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Inventor(s): Sheela Ramamoorthy
Keywords(s): Biology & Medicine
Category(s): Technologies > Biology & Medicine
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New Concept and Strategy Targeting COX-2 and D5D mediated Omega-6 Fatty Acid Metabolism for Cancer Treatment
Cyclo-oxygenase-2 (COX-2) over-expression is a known marker for cancer cell initiation, growth, and consequent metastasis. COX-2 catalyzes the oxidation of omega-6 fatty acid - arachidonic acid, producing metabolites such as prostaglandins that are known to initiate various cancers. Scientists at North Dakota State University have developed an anti-cancer...
Published: 11/24/2025
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Inventor(s): Steven Qian, Pinjing Zhao, Changhui Yan
Keywords(s): Biology & Medicine
Category(s): Technologies > Biology & Medicine
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MMP-9 Responsive PEG Cleavable Long Circulating Liposomes for Imaging and Treatment of Cancer
NDSU Scientists have developed a liposome-based delivery method with potential to reduce chemotherapy side effects while maintaining or even increasing cancer drug efficacy. The liposome is stabilized in the bloodstream using polyethylene glycol (PEG) and remains stable in the vicinity of healthy cells. However, upon arrival at a tumor the liposome...
Published: 11/24/2025
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Inventor(s): Sanku Mallik, Prajakta Kulkarni, Manas Haldar, D. K. Srivastava
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Category(s): Technologies > Biology & Medicine
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Monoclonal Antibody Against the Receptor for Advanced Glycation Endproducts
Scientists at NDSU have developed a monoclonal antibody that inhibits activation of the receptor for advanced glycation end products (RAGE). The antibody binds the V-domain to block activation of RAGE by its ligands. This antibody has delayed tumor growth in a xenograft melanoma model. The V-domain can bind multiple structurally and functionally diverse...
Published: 11/24/2025
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Inventor(s): Estelle Leclerc, Stefan Vetter
Keywords(s):
Category(s): Technologies > Biology & Medicine
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Total Ankle Replacement
NDSU engineers have developed an improved design and material for Total Ankle Replacements (TARs) that features an inverted design, in which the concave portion of the joint is on the bottom, and the convex on the top. This inverted design and the mode of assembly and implantation offers several benefits to surgeons and patients.
Benefits
Maintains...
Published: 11/24/2025
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Inventor(s): Chad Ulven, Fardad Azarmi, Jared Aelony
Keywords(s): Mechanical/Robotics
Category(s): Technologies > Biology & Medicine, Technologies > Mechanical/Robotics
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A Clinical Assay Named EvIPThT
Cancer detection methods traditionally rely on invasive procedures or single-marker assays that often yield false positives. This technology introduces a novel method for identifying tumor-derived extracellular vesicles (EVs) through antibody binding and beta-sheet structure analysis.
The process involves:
Combining an antibody with a sample to...
Published: 11/25/2025
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Inventor(s): Dali Sun
Keywords(s):
Category(s): Technologies, Technologies > Biology & Medicine
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Horizontal fluid flow bioreactor for cell growth, tissue engineering and cancer testbeds
The horizontal flow bioreactor is invented to facilitate continuous flow conditions to the cells grown on a tissue-engineered scaffold to mimic the interstitial fluid flow conditions around cells inside the body. The continuous fluid flow helps improve the mass transfer rates of cells and provides physical stimulus to the cells. Unlike the available...
Published: 11/25/2025
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Inventor(s): Dinesh Katti, Kalpana Katti, Haneesh Jasuja
Keywords(s):
Category(s): Technologies > Biology & Medicine
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Block-Scaffolds for Bone Regeneration Using Nanoclay-Polycaprolactone Scaffolds with Supplements
Researchers at NDSU have developed a versatile, modular scaffold for stem cell-based bone growth acceleration. The scaffold provides a structure that can be infused with stem cells, nutrients, cytokines, growth factors, therapeutics, bone morphogenetic protein, etc., enabling a highly adaptable treatment to address a wide variety of bone regeneration...
Published: 11/12/2025
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Inventor(s): Kalpana Katti, Dinesh Katti
Keywords(s): Biology & Medicine
Category(s): Technologies > Biology & Medicine, Technologies > Nanotechnology
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